Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule
2ICW
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Immune System
    Structure Weight: 188403.44
    Molecule: HLA class II histocompatibility antigen, DR alpha chain
    Polymer: 1 Type: protein Length: 179
    Chains: A, D
    Fragment: residues 28-206
    Organism: Homo sapiens
    Gene Names: Gene View for HLA-DRA HLA-DRA1
    UniProtKB: Protein Feature View | Search PDB | P01903  
    Molecule: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Polymer: 2 Type: protein Length: 190
    Chains: B, E
    Fragment: residues 30-219
    Organism: Homo sapiens
    Gene Name: Gene View for HLA-DRB1
    UniProtKB: Protein Feature View | Search PDB | P04229  
    Molecule: haemagglutinin peptide
    Polymer: 3 Type: protein Length: 13
    Chains: C, F
    Fragment: residues 306-318
    Molecule: Mycoplasma arthritidis mitogen
    Polymer: 4 Type: protein Length: 213
    Chains: G, H
    Fragment: residues 26-238
    Organism: Mycoplasma arthritidis
    UniProtKB: Protein Feature View | Search PDB | Q48898  
    Molecule: T-cell receptor alpha chain V
    Polymer: 5 Type: protein Length: 110
    Chains: I, K
    Fragment: residues 21-131
    Mutation: W82R, L43P
    Organism: Mus musculus
    UniProtKB: Protein Feature View | Search PDB | P01738  
    Molecule: T-cell receptor beta chain V
    Polymer: 6 Type: protein Length: 113
    Chains: J, L
    Mutation: G17E, G42E, L80S
    Organism: Mus musculus
    UniProtKB: Protein Feature View | Search PDB | A2NTY6  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 3
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 4
    Scientific Name: Mycoplasma arthritidis   Taxonomy   Expression System: Escherichia coli bl21(de3)  
    Polymer: 5
    Scientific Name: Mus musculus   Taxonomy   Common Name: House mouse Expression System: Escherichia coli bl21(de3)  
    Polymer: 6
    Scientific Name: Mus musculus   Taxonomy   Common Name: House mouse Expression System: Escherichia coli bl21(de3)  
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    MSE
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    MSE C5 H11 N O2 Se MET lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly 1       
Biological assembly 1 assigned by authors
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