Download MendeleyThe structure of human collapsin response mediator protein 2, a regulator of axonal growth.
Stenmark, P., Ogg, D., Flodin, S., Flores, A., Kotenyova, T., Nyman, T., Nordlund, P., Kursula, P.(2007) J Neurochem 101: 906-917
- PubMed: 17250651
- DOI: https://doi.org/10.1111/j.1471-4159.2006.04401.x
- Primary Citation of Related Structures:
2GSE - PubMed Abstract:
Axonal growth cone guidance is a central process in nervous system development and repair. Collapsin response mediator protein 2 (CRMP-2) is a neurite extension-promoting neuronal cytosolic molecule involved in the signalling of growth inhibitory cues from external stimuli, such as semaphorin 3A and the myelin-associated glycoprotein. We have determined the crystal structure of human tetrameric CRMP-2, which is structurally related to the dihydropyriminidases; however, the active site is not conserved. The wealth of earlier functional mapping data for CRMP-2 are discussed in light of the three-dimensional structure of the protein. The differences in oligomerisation interfaces between CRMP-1 and CRMP-2 are used to model CRMP-1/2 heterotetramers.
Organizational Affiliation:
Structural Genomics Consortium, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
