Download MendeleyHePTP Catalytic Domain (residues 44-339), S225D mutant
Page, R., Mustelin, T.To be published.
2GP0
HePTP Catalytic Domain (residues 44-339), S225D mutant
- PDB DOI: https://doi.org/10.2210/pdb2GP0/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2006-04-15 Released: 2006-05-09
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.206
- R-Value Work: 0.178
- R-Value Observed: 0.179
wwPDB Validation 3D Report Full Report
This is version 1.5 of the entry. See complete history.
Literature
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Tyrosine-protein phosphatase non-receptor type 7 | 309 | Homo sapiens | Mutation(s): 1 Gene Names: PTPN7 EC: 3.1.3.48 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P35236 (Homo sapiens) Explore P35236 Go to UniProtKB: P35236 | |||||
PHAROS: P35236 GTEx: ENSG00000143851 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P35236 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PO4 Query on PO4 | B [auth A] | PHOSPHATE ION O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-K |  | ||
| GOL Query on GOL | C [auth A] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.05 Å
- R-Value Free: 0.206
- R-Value Work: 0.178
- R-Value Observed: 0.179
- Space Group: P 61
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 127.52 | α = 90 |
| b = 127.52 | β = 90 |
| c = 60.133 | γ = 120 |
| Software Name | Purpose |
|---|---|
| DENZO | data reduction |
| SCALEPACK | data scaling |
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| CrystalClear | data reduction |
Entry History
Deposition Data
- Released Date: 2006-05-09 Deposition Author(s): Page, R.
Revision History (Full details and data files)
- Version 1.0: 2006-05-09
Type: Initial release - Version 1.1: 2008-05-01
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Non-polymer description, Version format compliance - Version 1.3: 2017-10-18
Changes: Refinement description - Version 1.4: 2021-10-20
Changes: Database references, Derived calculations - Version 1.5: 2023-08-30
Changes: Data collection, Refinement description
