Download MendeleyCrystal Structure of GRP94 with the specific mutation KS168-169AA; with bound Geldanamycin
Immormino, R.M., Metzger IV, L.E., Reardon, P.N., Gewirth, D.T.To be published.
2ESA
GRP94 n-terminal domain bound to geldanamycin: effects of mutants 168-169 KS-AA
- PDB DOI: https://doi.org/10.2210/pdb2ESA/pdb
- Classification: CHAPERONE
- Organism(s): Canis lupus familiaris
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): Yes
- Deposited: 2005-10-25 Released: 2006-10-03
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 Å
- R-Value Free: 0.213
- R-Value Work: 0.180
This is version 1.6 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Endoplasmin | 236 | Canis lupus familiaris | Mutation(s): 2 Gene Names: TRA1 |  | |
UniProt | |||||
Find proteins for P41148 (Canis lupus familiaris) Explore P41148 Go to UniProtKB: P41148 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P41148 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 3 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GDM Query on GDM | B [auth A] | GELDANAMYCIN C29 H40 N2 O9 QTQAWLPCGQOSGP-KSRBKZBZSA-N |  | ||
| PG4 Query on PG4 | C [auth A] | TETRAETHYLENE GLYCOL C8 H18 O5 UWHCKJMYHZGTIT-UHFFFAOYSA-N |  | ||
| PGE Query on PGE | D [auth A], E [auth A] | TRIETHYLENE GLYCOL C6 H14 O4 ZIBGPFATKBEMQZ-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.90 Å
- R-Value Free: 0.213
- R-Value Work: 0.180
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 47.33 | α = 90 |
| b = 66.39 | β = 90 |
| c = 75.87 | γ = 90 |
| Software Name | Purpose |
|---|---|
| CNS | refinement |
| HKL-2000 | data reduction |
| XDS | data scaling |
| MOLREP | phasing |
Entry History
Deposition Data
- Released Date: 2006-10-03 Deposition Author(s): Immormino, R.M., Metzger IV, L.E., Gewirth, D.T.
Revision History (Full details and data files)
- Version 1.0: 2006-10-03
Type: Initial release - Version 1.1: 2008-05-01
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2012-02-29
Changes: Non-polymer description - Version 1.4: 2017-08-02
Changes: Source and taxonomy - Version 1.5: 2021-10-20
Changes: Database references, Derived calculations - Version 1.6: 2023-08-23
Changes: Data collection, Refinement description
