2EC8
Crystal structure of the exctracellular domain of the receptor tyrosine kinase, Kit
- PDB DOI: https://doi.org/10.2210/pdb2EC8/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Spodoptera frugiperda
- Mutation(s): No 
- Deposited: 2007-02-11 Released: 2007-08-07 
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.295 
- R-Value Work: 0.254 
- R-Value Observed: 0.256 
This is version 1.2 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
Mast/stem cell growth factor receptor | 524 | Homo sapiens | Mutation(s): 0  Gene Names: KIT EC: 2.7.10.1 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P10721 (Homo sapiens) Explore P10721  Go to UniProtKB:  P10721 | |||||
PHAROS:  P10721 GTEx:  ENSG00000157404  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P10721 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
Ligands 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NAG Query on NAG | B [auth A], C [auth A], D [auth A], E [auth A], F [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 3.00 Å
- R-Value Free: 0.295 
- R-Value Work: 0.254 
- R-Value Observed: 0.256 
- Space Group: H 3
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 162.249 | α = 90 |
b = 162.249 | β = 90 |
c = 67.586 | γ = 120 |
Software Name | Purpose |
---|---|
CNS | refinement |
CBASS | data collection |
HKL-2000 | data reduction |
HKL-2000 | data scaling |
CNS | phasing |
REFMAC | refinement |
Entry History 
Deposition Data
- Released Date: 2007-08-07  Deposition Author(s): Yuzawa, S., Opatowsky, Y., Zhang, Z., Mandiyan, V., Lax, I., Schlessinger, J.
Revision History (Full details and data files)
- Version 1.0: 2007-08-07
Type: Initial release - Version 1.1: 2011-07-13
Changes: Advisory, Version format compliance - Version 1.2: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Data collection, Database references, Derived calculations, Structure summary