TNF Receptor Subtype One-selective TNF Mutant with Antagonistic Activity
2E7A
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Cytokine
    Structure Weight: 51898.50
    Molecule: Tumor necrosis factor
    Polymer: 1 Type: protein Length: 157
    Chains: A, B, C
    Mutation: K11M, K65S, A84S, V85T, S86T, Y87H, Q88N, T89Q, K90P, K98R, K112N, K128P
    Organism: Homo sapiens
    Gene Names: Gene View for TNF TNFA TNFSF2
    UniProtKB: Protein Feature View | Search PDB | P01375  
     
  •   Structure Validation Hide

    View the full validation report  

     

  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli bl21(de3)  
     
  •   Related PDB Entries Hide
    Identifier Details
    1TNF    
    1TNR    
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
Downloadable viewers:
 
 
 
  •   MyPDB Personal Annotations Hide
     
  •   Deposition Summary Hide
    Authors:   Mukai, Y.,  Yamagata, Y.,  Tsutsumi, Y.

    Deposition:   2007-01-09
    Release:   2007-11-13
    Last Modified (REVDAT):   2009-02-24
     
  •   Revision History    Hide
    Mouse over text for details
    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   1.80
    R-Value: 0.198 (work)
    R-Free: 0.239
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 64.56 α = 90.00 
    b = 66.97 β = 90.00 
    c = 103.56 γ = 90.00