Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound     DOI:10.2210/pdb2a4g/pdb

2A4G Display Files close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header) Download Files close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A+S) Print this Page Share this Page close Email Delicious Stumble Google More... Link this Page

Primary Citation       Related Citations in PDB Entry (REMARK 1) Hide       Molecular Description Hide Classification: Viral Protein Structure Weight: 48072.33   Molecule: NS3 protease/helicase Polymer: 1 Type: polypeptide(L) Length: 200 Chains: A, C Fragment: protease domain, residues 1-181 Molecule: NS4a peptide Polymer: 2 Type: polypeptide(L) Length: 23 Chains: B, D Fragment: residues 21-39       Source Hide Polymer: 1 Scientific Name: Hepatitis c virus Expression System: Escherichia coli   Polymer: 2 Scientific Name: Synthetic construct         Ligand Chemical Component Hide Identifier Name Formula Interaction View UNH     ({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]- METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL) -3-METHYL- BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC ACID ISOBUTYL ESTER C35 H54 N6 O8 Ligand Explorer ZN     ZINC ION Zn Ligand Explorer       Derived Data Hide CATH Classification v3.3.0 - (4 Domains) PFAM Classification - (4 Domains)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Arasappan, A.,   Njoroge, F.G.,   Chan, T.Y.,   Bennett, F.,   Bogen, S.L.,   Chen, K.,   Gu, H.,   Hong, L.,   Jao, E.,   Liu, Y.T.,   Lovey, R.G.,   Parekh, T.,   Pike, R.E.,   Pinto, P.,   Santhanam, B.,   Venkatraman, S.,   Vaccaro, H.,   Wang, H.,   Yang, X.,   Zhu, Z.,   Mckittrick, B.,   Saksena, A.K.,   Girijavallabhan, V.,   Pichardo, J.,   Butkiewicz, N.,   Ingram, R.,   Malcolm, B.,   Prongay, A.J.,   Yao, N.,   Marten, B.,   V.,   Madison,   Kemp, S.,   Levy, O.,   Lim-Wilby, M.,   Tamura, S.,   Ganguly, A.K. Deposition:   2005-06-28 Release:   2006-07-04 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 2.50 R-Value: 0.193 (work) R-Free: 0.265 Space Group: H 3 2 Unit Cell:   Length [Å] Angles [°] a = 224.39 α = 90.00  b = 224.39 β = 90.00  c = 75.33 γ = 120.00