Crystal Structure of HIV-1 Reverse Transcriptase (RT) in Complex with TMC278 (Rilpivirine), A Non-nucleoside RT Inhibitor     DOI:10.2210/pdb2zd1/pdb

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Primary Citation       Molecular Description Hide Classification: Transferase , Hydrolase Structure Weight: 114554.65   Molecule: Reverse transcriptase/ribonuclease H Polymer: 1 Type: polypeptide(L) Length: 557 Chains: A EC#: 2.7.7.49   2.7.7.7   3.1.26.4    Fragment: P66 Mutation: C280S, K172A, K173A Molecule: p51 RT Polymer: 2 Type: polypeptide(L) Length: 428 Chains: B Fragment: P51 Mutation: C280S       Source Hide Polymer: 1 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 2 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli         Related PDB Entries Hide Id Details 1S6Q    1SV5    2IC3    2ZE2    3BGR          Ligand Chemical Component Hide Identifier Name Formula Interaction View Links EDO     1,2-ETHANEDIOL C2 H6 O2 Ligand Explorer SO4     SULFATE ION O4 S Ligand Explorer T27     4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin- 2 -yl]amino}benzonitrile C22 H18 N6 Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (1 Domains) CATH Classification v3.2.0 - (9 Domains) PFAM Classification - (7 Domains) GO Terms - (68 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Das, K.,   Bauman, J.D.,   Clark Jr., A.D.,   Shatkin, A.J.,   Arnold, E. Deposition:   2007-11-16 Release:   2008-02-12 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 1.80 R-Value: 0.220 (obs.) R-Free: 0.248 Space Group: C 2 Unit Cell:   Length [Å] Angles [°] a = 163.37 α = 90.00  b = 73.26 β = 100.07  c = 110.07 γ = 90.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase