Download MendeleyTargeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors
Igonet, S., Vaney, M.C., Bartonova, V., Helma, J., Rothbauer, U., Leonhardt, H., Stura, E., Krausslich, H.-G., Rey, F.A.To be published.
2XV6
Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 220) in complex with a camelid VHH.
- PDB DOI: https://doi.org/10.2210/pdb2XV6/pdb
- Classification: VIRAL PROTEIN/IMMUNE SYSTEM
- Organism(s): Human immunodeficiency virus 1, Vicugna pacos
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2010-10-22 Released: 2011-10-12
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.89 Å
- R-Value Free: 0.195
- R-Value Work: 0.175
- R-Value Observed: 0.176
wwPDB Validation 3D Report Full Report
This is version 1.2 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| CAPSID PROTEIN P24 | 75 | Human immunodeficiency virus 1 | Mutation(s): 0 |  | |
UniProt | |||||
Find proteins for P12497 (Human immunodeficiency virus type 1 group M subtype B (isolate NY5)) Explore P12497 Go to UniProtKB: P12497 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P12497 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| CAMELID VHH 9 | 121 | Vicugna pacos | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.89 Å
- R-Value Free: 0.195
- R-Value Work: 0.175
- R-Value Observed: 0.176
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 34.451 | α = 90 |
| b = 60.118 | β = 99.7 |
| c = 96.662 | γ = 90 |
| Software Name | Purpose |
|---|---|
| BUSTER | refinement |
| XDS | data reduction |
| SCALA | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2011-10-12 Deposition Author(s): Igonet, S., Vaney, M.C., Bartonova, V., Helma, J., Rothbauer, U., Leonhardt, H., Stura, E., Krausslich, H.-G., Rey, F.A.
Revision History (Full details and data files)
- Version 1.0: 2011-10-12
Type: Initial release - Version 1.1: 2019-08-14
Changes: Data collection, Database references, Structure summary - Version 1.2: 2023-12-20
Changes: Data collection, Database references, Other, Refinement description
