2XT1

Crystal structure of the HIV-1 capsid protein C-terminal domain (146- 231) in complex with a camelid VHH.


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 1.32 Å
  • R-Value Free: 0.183 
  • R-Value Work: 0.161 
  • R-Value Observed: 0.162 

wwPDB Validation   3D Report Full Report


This is version 1.3 of the entry. See complete history


Literature

Targeting HIV-1 Virion Formation with Nanobodies -Implications for the Design of Assembly Inhibitors

Igonet, S.Vaney, M.C.Bartonova, V.Helma, J.Rothbauer, U.Leonhardt, H.Stura, E.Krausslich, H.-G.Rey, F.A.

To be published.

Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
GAG POLYPROTEIN86Human immunodeficiency virus 1Mutation(s): 0 
UniProt
Find proteins for Q71B32 (Human immunodeficiency virus 1)
Explore Q71B32 
Go to UniProtKB:  Q71B32
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ71B32
Sequence Annotations
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  • Reference Sequence
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
CAMELID VHH 9121Vicugna pacosMutation(s): 0 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
Sequence Annotations
Expand
  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 1.32 Å
  • R-Value Free: 0.183 
  • R-Value Work: 0.161 
  • R-Value Observed: 0.162 
  • Space Group: P 21 21 2
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 60.06α = 90
b = 88.17β = 90
c = 35.66γ = 90
Software Package:
Software NamePurpose
BUSTERrefinement
XDSdata reduction
SCALAdata scaling
PHASERphasing

Structure Validation

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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2011-10-12
    Type: Initial release
  • Version 1.1: 2018-06-20
    Changes: Data collection, Derived calculations
  • Version 1.2: 2019-08-14
    Changes: Data collection, Database references, Structure summary
  • Version 1.3: 2023-12-20
    Changes: Data collection, Database references, Derived calculations, Other, Refinement description