THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH SW13.
2WXG
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 108331.53
    Molecule: PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM
    Polymer: 1 Type: protein Length: 940
    Chains: A
    EC#: 2.7.1.153   
    Fragment: RESIDUES 106-1044
    Organism: Mus musculus
    Gene Name: Pik3cd
    UniProtKB: Protein Feature View | Search PDB | O35904  
     
  •   Structure Validation Hide

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  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Mus musculus   Taxonomy   Common Name: House mouse Expression System: Spodoptera frugiperda  
     
  •   Related PDB Entries Hide
    Identifier Details
    2WXE   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH IC87114. 
    2WXF   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH PIK-39. 
    2WXH   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH SW14. 
    2WXI   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH SW30. 
    2WXJ   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH INK654. 
    2WXK   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH INK666. 
    2WXL   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH ZSTK474. 
    2WXM   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH DL06. 
    2WXN   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH DL06. 
    2WXO   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH AS5. 
    2WXP   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH GDC-0941. 
    2WXQ   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA IN COMPLEX WITH AS15. 
    2WXR   THE CRYSTAL STRUCTURE OF THE MURINE CLASS IA PI 3-KINASE P110DELTA. 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    ZZN
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    ZZN C28 H22 F N7 O2
    2-{[4-amino-3-(3-fluoro-5-hydroxyphenyl)- 1H-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}- 5-methyl-3-(2-methylphenyl)quinazolin-4(3H)- one
    ZZN:2WXG
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    ZZN
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    ZZN
    IC50: 0.7 nM (94) - data from BindingDB  
    IC50: 0.7 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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