2REN
STRUCTURE OF RECOMBINANT HUMAN RENIN, A TARGET FOR CARDIOVASCULAR-ACTIVE DRUGS, AT 2.5 ANGSTROMS RESOLUTION
- PDB DOI: https://doi.org/10.2210/pdb2REN/pdb
- Classification: HYDROLASE(ACID PROTEINASE)
- Organism(s): Homo sapiens
- Mutation(s): No 
- Deposited: 1992-02-05 Released: 1994-01-31 
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.50 Å
- R-Value Observed: 0.217 
wwPDB Validation   3D Report Full Report
This is version 1.4 of the entry. See complete history. 
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
---|---|---|---|---|---|
Molecule | Chains | Sequence Length | Organism | Details | Image |
RENIN | 340 | Homo sapiens | Mutation(s): 0  EC: 3.4.23.15 | ||
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P00797 (Homo sapiens) Explore P00797  Go to UniProtKB:  P00797 | |||||
PHAROS:  P00797 GTEx:  ENSG00000143839  | |||||
Entity Groups   | |||||
Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
UniProt Group | P00797 | ||||
Sequence AnnotationsExpand | |||||
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Small Molecules
Ligands 1 Unique | |||||
---|---|---|---|---|---|
ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
NAG Query on NAG | B [auth A] | 2-acetamido-2-deoxy-beta-D-glucopyranose C8 H15 N O6 OVRNDRQMDRJTHS-FMDGEEDCSA-N |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.50 Å
- R-Value Observed: 0.217 
- Space Group: I 4
Unit Cell:
Length ( Å ) | Angle ( ˚ ) |
---|---|
a = 134.08 | α = 90 |
b = 134.08 | β = 90 |
c = 41.98 | γ = 90 |
Software Name | Purpose |
---|---|
X-PLOR | model building |
GROMOS | refinement |
PROLSQ | refinement |
X-PLOR | refinement |
X-PLOR | phasing |
Entry History 
Deposition Data
- Released Date: 1994-01-31  Deposition Author(s): Sielecki, A.R., James, M.N.G.
Revision History (Full details and data files)
- Version 1.0: 1994-01-31
Type: Initial release - Version 1.1: 2008-03-25
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Non-polymer description, Version format compliance - Version 1.3: 2017-11-29
Changes: Derived calculations, Other - Version 1.4: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Advisory, Data collection, Derived calculations, Structure summary