Structure of a human p110alpha/p85alpha complex
2RD0
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase/oncoprotein
    Structure Weight: 161490.30
    Molecule: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
    Polymer: 1 Type: protein Length: 1096
    Chains: A
    EC#: 2.7.1.153    2.7.11.1   
    Organism: Homo sapiens
    Gene Name: Gene View for PIK3CA
    UniProtKB: Protein Feature View | Search PDB | P42336  
    Molecule: Phosphatidylinositol 3-kinase regulatory subunit alpha
    Polymer: 2 Type: protein Length: 279
    Chains: B
    Fragment: UNP residues 322-600
    Organism: Homo sapiens
    Gene Names: Gene View for PIK3R1 GRB1
    UniProtKB: Protein Feature View | Search PDB | P27986  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Huang, C.,  Gabelli, S.B.,  Amzel, L.M.

    Deposition:   2007-09-20
    Release:   2007-12-25
    Last Modified (REVDAT):   2011-07-13
     
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    2011-07-13
    Flag residual B-value
    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   3.05
    R-Value: 0.267 (obs.)
    R-Free: 0.323
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 115.06 α = 90.00 
    b = 117.05 β = 90.00 
    c = 151.58 γ = 90.00