2R0L

Short Form HGFA with Inhibitory Fab75

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.20 Å
  • R-Value Free: 0.248 
  • R-Value Work: 0.193 
  • R-Value Observed: 0.195 

wwPDB Validation   3D Report Full Report


This is version 2.1 of the entry. See complete history. 



Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
antibody light chainA [auth L]214Homo sapiens, synthetic construct
This entity is chimeric		Mutation(s): 0 
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Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
antibody heavy chain, Fab portion onlyB [auth H]220Homo sapiens, synthetic construct
This entity is chimeric		Mutation(s): 0 
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Entity ID: 3
MoleculeChains Sequence LengthOrganismDetailsImage
Hepatocyte growth factor activatorC [auth A]248Homo sapiensMutation(s): 0 
Gene Names: HGFAC
EC: 3.4.21
UniProt & NIH Common Fund Data Resources
Find proteins for Q04756 (Homo sapiens)
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Go to UniProtKB:  Q04756
PHAROS:  Q04756
GTEx:  ENSG00000109758 
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UniProt GroupQ04756
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Entity ID: 4
MoleculeChains Sequence LengthOrganismDetailsImage
Hepatocyte growth factor activatorD [auth B]35Homo sapiensMutation(s): 0 
Gene Names: HGFAC
UniProt & NIH Common Fund Data Resources
Find proteins for Q04756 (Homo sapiens)
Explore Q04756 
Go to UniProtKB:  Q04756
PHAROS:  Q04756
GTEx:  ENSG00000109758 
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UniProt GroupQ04756
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Oligosaccharides

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Entity ID: 5
MoleculeChains Length2D Diagram Glycosylation3D Interactions
beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranoseE [auth C]3N-Glycosylation
Glycosylation Resources
GlyTouCan:  G15407YE
GlyCosmos:  G15407YE
GlyGen:  G15407YE
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.20 Å
  • R-Value Free: 0.248 
  • R-Value Work: 0.193 
  • R-Value Observed: 0.195 
  • Space Group: P 1
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 38.82α = 98.39
b = 48.23β = 96.24
c = 97.05γ = 100.77
Software Package:
Software NamePurpose
REFMACrefinement
Blu-Icedata collection
HKL-2000data reduction
HKL-2000data scaling
PHASERphasing

Structure Validation

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Entry History 

Deposition Data

Revision History  (Full details and data files)

  • Version 1.0: 2007-12-25
    Type: Initial release
  • Version 1.1: 2011-07-13
    Changes: Advisory, Version format compliance
  • Version 1.2: 2013-09-25
    Changes: Source and taxonomy
  • Version 1.3: 2017-10-25
    Changes: Advisory, Refinement description
  • Version 2.0: 2020-07-29
    Type: Remediation
    Reason: Carbohydrate remediation
    Changes: Atomic model, Data collection, Derived calculations, Structure summary
  • Version 2.1: 2023-08-30
    Changes: Advisory, Data collection, Database references, Refinement description, Structure summary