2PSO

Human StarD13 (DLC2) lipid transfer and protein localization domain


Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.80 Å
  • R-Value Free: 0.244 
  • R-Value Work: 0.210 
  • R-Value Observed: 0.211 

wwPDB Validation   3D Report Full Report


This is version 1.5 of the entry. See complete history


Literature

Comparative structural analysis of lipid binding START domains.

Thorsell, A.G.Lee, W.H.Persson, C.Siponen, M.I.Nilsson, M.Busam, R.D.Kotenyova, T.Schuler, H.Lehtio, L.

(2011) PLoS One 6: e19521-e19521

  • DOI: https://doi.org/10.1371/journal.pone.0019521
  • Primary Citation of Related Structures:  
    2PSO, 2R55, 3FO5, 3P0L

  • PubMed Abstract: 

    Steroidogenic acute regulatory (StAR) protein related lipid transfer (START) domains are small globular modules that form a cavity where lipids and lipid hormones bind. These domains can transport ligands to facilitate lipid exchange between biological membranes, and they have been postulated to modulate the activity of other domains of the protein in response to ligand binding. More than a dozen human genes encode START domains, and several of them are implicated in a disease.


  • Organizational Affiliation

    Department of Medical Biochemistry and Biophysics, Structural Genomics Consortium, Karolinska Institutet, Stockholm, Sweden.


Macromolecules
Find similar proteins by:  (by identity cutoff)  |  3D Structure
Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
StAR-related lipid transfer protein 13
A, B, C
237Homo sapiensMutation(s): 0 
Gene Names: STARD13DLC2GT650
Membrane Entity: Yes 
UniProt & NIH Common Fund Data Resources
Find proteins for Q9Y3M8 (Homo sapiens)
Explore Q9Y3M8 
Go to UniProtKB:  Q9Y3M8
PHAROS:  Q9Y3M8
GTEx:  ENSG00000133121 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
UniProt GroupQ9Y3M8
Sequence Annotations
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  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 2.80 Å
  • R-Value Free: 0.244 
  • R-Value Work: 0.210 
  • R-Value Observed: 0.211 
  • Space Group: P 43
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 78.24α = 90
b = 78.24β = 90
c = 212.72γ = 90
Software Package:
Software NamePurpose
REFMACrefinement
ProDCdata collection
XDSdata reduction
XSCALEdata scaling
PHASERphasing
MOLREPphasing

Structure Validation

View Full Validation Report



Entry History 

Revision History  (Full details and data files)

  • Version 1.0: 2007-05-15
    Type: Initial release
  • Version 1.1: 2008-05-01
    Changes: Version format compliance
  • Version 1.2: 2011-07-13
    Changes: Advisory, Version format compliance
  • Version 1.3: 2011-09-21
    Changes: Database references
  • Version 1.4: 2017-10-18
    Changes: Refinement description
  • Version 1.5: 2023-08-30
    Changes: Data collection, Database references, Refinement description