POP-OUT | CLOSE
 
Crystal Structure of the multi-drug resistant mutant subtype F HIV protease complexed with TL-3 inhibitor
2P3D
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase/hydrolase Inhibitor
    Structure Weight: 22634.89
    Molecule: Pol protein
    Polymer: 1 Type: protein Length: 99
    Chains: A, B
    EC#: 3.4.23.16   
    Fragment: HIV-1 protease
    Mutation: Q7K
    Organism: Human immunodeficiency virus 1
    Gene Name: pol
    UniProtKB: Protein Feature View | Search PDB | Q7SRY5  
     
  •   Structure Validation Hide

    Download full validation report    

     

  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
     
  •   Related PDB Entries Hide
    Identifier Details
    2P3A  Crystal Structure of the multi-drug resistant mutant subtype B HIV protease complexed with TL-3 inhibitor 
    2P3B  Crystal Structure of the subtype B wild type HIV protease complexed with TL-3 inhibitor 
    2P3C  Crystal Structure of the subtype F wild type HIV protease complexed with TL-3 inhibitor 
     
  •   Biologically Interesting Molecules (BIRD) Hide
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    3TL
    Search 
    Download 
    3TL C50 H64 N6 O10
    benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10- dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13- bis(1-methylethyl)-2,5,12,15,18-pentaoxo- 20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos- 1-yl]carbamate
    3TL:2P3D
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
Downloadable viewers:
 
 
 
  •   MyPDB Personal Annotations Hide
     
  •   Deposition Summary Hide
    Authors:   Sanches, M.,  Krauchenco, S.,  Martins, N.H.,  Gustchina, A.,  Wlodawer, A.,  Polikarpov, I.

    Deposition:   2007-03-08
    Release:   2007-04-24
    Last Modified (REVDAT):   2011-07-13
     
  •   Revision History    Hide
    Mouse over text for details
    2013-02-27
    Other
    2011-07-13
    Atom nomenclature
    2011-07-13
    Binding sites and description
    2011-07-13
    Non-polymer description
    2011-07-13
    Function and keywords
    2011-07-13
    Linkage
    2011-07-13
    Sequence database correspondence
    2011-07-13
    Polymer description
    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.80
    R-Value: 0.190 (obs.)
    R-Free: 0.260
    Space Group: P 61
    Unit Cell:
      Length [Å] Angles [°]
    a = 61.25 α = 90.00 
    b = 61.25 β = 90.00 
    c = 82.23 γ = 120.00