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Crystal Structure of K101E Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
 
 
DOI:10.2210/pdb2opr/pdb
2OPR
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase
    Structure Weight: 113443.09
     
    Molecule:Reverse transcriptase/ribonuclease H
    Polymer:1Type:polypeptide(L)Length:547
    Chains:A
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P66
    Mutation:K101E
    Molecule:p51 RT
    Polymer:2Type:polypeptide(L)Length:426
    Chains:B
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:P51
    Mutation:K101E
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Hiv-1 m:b_hxb2r Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Hiv-1 m:b_hxb2r Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    HBQ     ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4- DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE C14 H17 F N2 O3 3DLigand Explorer Link out to Ligand Expos:HBQ Link out to SuperLigands:HBQ Link out to SuperHapten:HBQ
     
     
  •  
    Move Section Modified Residues Hide
    Identifier Name Formula Interaction View Links
    CSW CYSTEINE-S-DIOXIDE (parent: CYS)(type: lPeptideLinking) C3 H7 N O4 S 3D Ligand Explorer Link out to Ligand Expos:CSW Link out to SuperLigands:CSW Link out to SuperHapten:CSW 2D
     
     
  •  
    Move Section Derived Data Hide
     
     
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Ren, J.,   Nichols, C.E.,   Chamberlain, P.P.,   Weaver, K.L.,   Short, S.A.,   Chan, J.H.,   Kleim, J.,   Stammers, D.K.

    Deposition:   2007-01-30
    Release:   2007-05-22
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.90
    R-Value: 0.232 (obs.)
    R-Free: 0.303
    Space Group: P 21 21 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 138.00 α = 90.00 
    b = 109.30 β = 90.00 
    c = 72.40 γ = 90.00