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Crystal Structure of L100I Mutant HIV-1 Reverse Transcriptase in Complex with GW420867X.
2OPQ
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 111986.47
    Molecule: Reverse transcriptase/ribonuclease H
    Polymer: 1 Type: protein Length: 534
    Chains: A
    EC#: 2.7.7.49    2.7.7.7    3.1.26.13   
    Fragment: P66
    Mutation: Leu100Ile
    Organism: HIV-1 M:B_HXB2R
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
    Molecule: p51 RT
    Polymer: 2 Type: protein Length: 424
    Chains: B
    EC#: 2.7.7.49   
    Fragment: P51
    Mutation: Leu100Ile
    Organism: HIV-1 M:B_HXB2R
    Gene Name: pol
    UniProtKB: Protein Feature View | Search PDB | Q74085  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Hiv-1 m:b_hxb2r   Taxonomy   Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Hiv-1 m:b_hxb2r   Taxonomy   Expression System: Escherichia coli  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    HBQ
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    HBQ C14 H17 F N2 O3
    ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4- DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE
    HBQ:2OPQ
    PO4
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    PO4 O4 P
    PHOSPHATE ION
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    HBQ
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    HBQ
    IC50: 179 nM (99) - data from BindingDB  
    N/Ain BindingMoad
    N/Ain PDBbind
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    CSW
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    CSW C3 H7 N O4 S CYS lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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