Crystal Structure of HIV-1 Reverse Transcriptase in Complex with GW420867X.     DOI:10.2210/pdb2opp/pdb

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Primary Citation       Molecular Description Hide Classification: Transferase Structure Weight: 113309.02   Molecule: Reverse transcriptase/ribonuclease H Polymer: 1 Type: polypeptide(L) Length: 542 Chains: A EC#: 2.7.7.49    Fragment: P66 Molecule: p51 RT Polymer: 2 Type: polypeptide(L) Length: 427 Chains: B EC#: 2.7.7.49    Fragment: P51       Source Hide Polymer: 1 Scientific Name: Hiv-1 m:b_hxb2r Expression System: Escherichia coli   Polymer: 2 Scientific Name: Hiv-1 m:b_hxb2r Expression System: Escherichia coli         Ligand Chemical Component Hide Identifier Name Formula Interaction View Links HBQ     ISOPROPYL (2S)-2-ETHYL-7-FLUORO-3-OXO-3,4- DIHYDROQUINOXALINE-1(2H)-CARBOXYLATE C14 H17 F N2 O3 Ligand Explorer MG     MAGNESIUM ION Mg Ligand Explorer PO4     PHOSPHATE ION O4 P Ligand Explorer       Modified Residues Hide Identifier Name Formula Interaction View Links CSW CYSTEINE-S-DIOXIDE (parent: CYS)(type: lPeptideLinking) C3 H7 N O4 S Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (2 Domains) CATH Classification v3.2.0 - (9 Domains) PFAM Classification - (7 Domains) GO Terms - (70 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Ren, J.,   Nichols, C.E.,   Chamberlain, P.P.,   Weaver, K.L.,   Chan, S.J.H.,   Kleim, J.,   Stammers, D.K. Deposition:   2007-01-30 Release:   2007-05-22 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 2.55 R-Value: 0.205 (obs.) R-Free: 0.295 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 138.50 α = 90.00  b = 115.30 β = 90.00  c = 65.90 γ = 90.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase