Download MendeleyCrystal Structure of Human Prolidase: The Molecular Basis of PD Disease.
MUELLER, U., NIESEN, F.H., ROSKE, Y., GOETZ, F., BEHLKE, J., BUESSOW, K., HEINEMANN, U.To be published.
2OKN
Crystal Strcture of Human Prolidase
- PDB DOI: https://doi.org/10.2210/pdb2OKN/pdb
- Classification: HYDROLASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): Yes
- Deposited: 2007-01-17 Released: 2007-02-20
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.45 Å
- R-Value Free: 0.231
- R-Value Work: 0.178
- R-Value Observed: 0.180
wwPDB Validation 3D Report Full Report
This is version 1.5 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Xaa-Pro dipeptidase | 494 | Homo sapiens | Mutation(s): 1 Gene Names: PEPD, PRD EC: 3.4.13.9 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P12955 (Homo sapiens) Explore P12955 Go to UniProtKB: P12955 | |||||
PHAROS: P12955 GTEx: ENSG00000124299 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P12955 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| PI Query on PI | E [auth A], H [auth B], I [auth B] | HYDROGENPHOSPHATE ION H O4 P NBIIXXVUZAFLBC-UHFFFAOYSA-L |  | ||
| MN Query on MN | C [auth A], D [auth A], F [auth B], G [auth B] | MANGANESE (II) ION Mn WAEMQWOKJMHJLA-UHFFFAOYSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.45 Å
- R-Value Free: 0.231
- R-Value Work: 0.178
- R-Value Observed: 0.180
- Space Group: C 2 2 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 103.89 | α = 90 |
| b = 108.96 | β = 90 |
| c = 212.01 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| PDB_EXTRACT | data extraction |
| MAR345 | data collection |
| XDS | data reduction |
| XSCALE | data scaling |
Entry History
Deposition Data
- Released Date: 2007-02-20 Deposition Author(s): Mueller, U., Niesen, F.H., Roske, Y., Goetz, F., Behlke, J., Buessow, K., Heinemann, U., Protein Structure Factory (PSF)
Revision History (Full details and data files)
- Version 1.0: 2007-02-20
Type: Initial release - Version 1.1: 2008-04-01
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Advisory, Derived calculations, Version format compliance - Version 1.3: 2017-10-18
Changes: Refinement description - Version 1.4: 2021-10-20
Changes: Database references, Derived calculations - Version 1.5: 2023-08-30
Changes: Data collection, Refinement description
