Crystal Structure of HIV-1 Protease (Q7K, I50V) in Complex with Tipranavir
2O4L
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Viral Protein
    Structure Weight: 22439.56
    Molecule: protease
    Polymer: 1 Type: protein Length: 99
    Chains: A, B
    EC#: 3.4.23.16   
    Mutation: Q7K, I50V
    Organism: Human immunodeficiency virus 1
    Gene Names: gag-pol pol
    UniProtKB: Protein Feature View | Search PDB | P03367  

    UniProtKB: Protein Feature View | Search PDB | Q1G1C3  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    CL
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    CL Cl
    CHLORIDE ION
    GOL
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    GOL C3 H8 O3
    GLYCEROL
    TPV
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    TPV C31 H33 F3 N2 O5 S
    N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL- 6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)- 5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE
    TPV:2O4L
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    TPV
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    TPV
    Ki: 0.008 - 0.032 nM (96) - data from BindingDB  
    Kd: 0.608 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA,PQS (software)
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