Crystal structure of HIV1 protease in situ product complex
2NPH
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 22625.83
    Molecule: PROTEASE RETROPEPSIN
    Polymer: 1 Type: protein Length: 99
    Chains: A, B
    EC#: 3.4.23.16   
    Details: Observation of a Low Barrier Hydrogen Bond between catalytic aspartates
    Organism: Human immunodeficiency virus 1
    Gene Name: gag-pol
    UniProtKB: Protein Feature View | Search PDB | P04585  
    Molecule: tetrapeptide fragment
    Polymer: 2 Type: protein Length: 4
    Chains: S
    Molecule: pentapeptide fragment
    Polymer: 3 Type: protein Length: 5
    Chains: T
     
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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1   Taxonomy   Expression System: Escherichia coli bl21(de3)  
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 3
    Scientific Name: Synthetic construct   Taxonomy    
     
  •   Related PDB Entries Hide
    Identifier Details
    1G6L   Unliganded closed-flap structure of tethered HIV-1 PR 
    1LV1   Unliganded closed-flap structure of C1095A mutant of tethered HIV-1 PR 
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Hosur, M.V.,  Das, A.,  Prashar, V.

    Deposition:   2006-10-27
    Release:   2006-12-19
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
    Version format compliance
     
  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   1.65
    R-Value: 0.216 (obs.)
    R-Free: 0.259
    Space Group: P 61
    Unit Cell:
      Length [Å] Angles [°]
    a = 62.03 α = 90.00 
    b = 62.03 β = 90.00 
    c = 81.78 γ = 120.00