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Crystal structure of HIV1 protease in situ product complex
 
 
DOI:10.2210/pdb2nph/pdb
2NPH
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Hydrolase
    Structure Weight: 22625.83
     
    Molecule:PROTEASE RETROPEPSIN
    Polymer:1Type:polypeptide(L)Length:99
    Chains:A, B
    EC#:3.4.23.16 Go to IUBMB EC entry  
    Other Details:Observation of a Low Barrier Hydrogen Bond between catalytic aspartates
    Molecule:tetrapeptide fragment
    Polymer:2Type:polypeptide(L)Length:4
    Chains:S
    Molecule:pentapeptide fragment
    Polymer:3Type:polypeptide(L)Length:5
    Chains:T
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus 1 Go to NCBI Taxonomy entry Expression System: Escherichia coli bl21(de3)  
    Polymer: 2
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
    Polymer: 3
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1G6L  Unliganded closed-flap structure of tethered HIV-1 PR 
    1LV1  Unliganded closed-flap structure of C1095A mutant of tethered HIV-1 PR 
     
     
  •  
    Move Section Derived Data Hide
     
     
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< Biological Assembly    Help
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Hosur, M.V.,   Das, A.,   Prashar, V.

    Deposition:   2006-10-27
    Release:   2006-12-19
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   N/A
    View a histogram of Resolution Resolution[Å]: 1.65
    R-Value: 0.216 (obs.)
    R-Free: 0.259
    Space Group: P 61
    Unit Cell:
      Length [Å] Angles [°]
    a = 62.03 α = 90.00 
    b = 62.03 β = 90.00 
    c = 81.78 γ = 120.00