Download MendeleyRole of the microcin B17 propeptide in substrate recognition: solution structure and mutational analysis of McbA1-26.
Roy, R.S., Kim, S., Baleja, J.D., Walsh, C.T.(1998) Chem Biol 5: 217-228
- PubMed: 9545435
- DOI: https://doi.org/10.1016/s1074-5521(98)90635-4
- Primary Citation of Related Structures:
2MLP - PubMed Abstract:
The peptide antibiotic microcin B17 (MccB17) contains oxazole and thiazole heterocycles formed by the post-translational modification of four cysteine and four serine residues. An amino-terminal propeptide targets the 69 amino acid precursor of MccB17 (preproMccB17) to the heterocyclization enzyme MccB17 synthetase. The mode of synthetase recognition has been unclear, because there has been limited structural information available on the MccB17 propeptide to date.
Organizational Affiliation:
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
