2KHX

Solution structure of the Drosha double-stranded RNA-binding domain.

(2010) Silence 1: 2-2

• PubMed: 20226070 Search on PubMedSearch on PubMed Central
• DOI: https://doi.org/10.1186/1758-907X-1-2
• Primary Citation of Related Structures:  
  2KHX


• PubMed Abstract: 
  

  Drosha is a nuclear RNase III enzyme that initiates processing of regulatory microRNA. Together with partner protein DiGeorge syndrome critical region 8 (DGCR8), it forms the Microprocessor complex, which cleaves precursor transcripts called primary microRNA to produce hairpin precursor microRNA. In addition to two RNase III catalytic domains, Drosha contains a C-terminal double-stranded RNA-binding domain (dsRBD). To gain insight into the function of this domain, we determined the nuclear magnetic resonance (NMR) solution structure.

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Organizational Affiliation: 

Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA.