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Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
 
 
DOI:10.2210/pdb2iaj/pdb
2IAJ
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Transferase
    Structure Weight: 117276.98
     
    Molecule:Reverse transcriptase/ribonuclease H (p66 RT)
    Polymer:1Type:polypeptide(L)Length:560
    Chains:A
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:p66
    Mutation:K103N, Y181C, C280S
    Molecule:Reverse transcriptase/ribonuclease H; p51 RT
    Polymer:2Type:polypeptide(L)Length:447
    Chains:B
    EC#:2.7.7.49 Go to IUBMB EC entry  
    Fragment:p51
    Mutation:K103N, Y181C, C280S
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Human immunodeficiency virus type 1 bh10 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Human immunodeficiency virus type 1 bh10 Go to NCBI Taxonomy entry Expression System: Escherichia coli  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1BQM  1S9E IS THE STRUCTURE OF HIV-1 RT/HBY 097 
    1DLO  1DLO IS THE STRUCTURE OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 
    1SV5  1SV5 IS THE STRUCTURE OF K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH JANSSEN-R165335 
    1UWB  1HNV IS THE STRUCTURE OF TYR 181 CYS HIV-1 RT/8-CL TIBO 
    2HMI  2HMI IS HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH A DOUBLE-STRANDED DNA AND FAB28 
    2IC3  2IC3 IS THE STRUCTURE OF K103N/Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NONNUCLEOSIDE INHIBITOR HBY 097 
     
     
  •  
    Move Section Ligand Chemical Component Hide
    Identifier Name Formula Interaction View Links
    ATP     ADENOSINE-5'-TRIPHOSPHATE C10 H16 N5 O13 P3 3DLigand Explorer Link out to Ligand Expos:ATP Link out to SuperLigands:ATP Link out to SuperHapten:ATP
    GOL     GLYCEROL C3 H8 O3 3DLigand Explorer Link out to Ligand Expos:GOL Link out to SuperLigands:GOL Link out to SuperHapten:GOL
    MN     MANGANESE (II) ION Mn 3DLigand Explorer Link out to Ligand Expos:MN Link out to SuperLigands:MN Link out to SuperHapten:MN
    NA     SODIUM ION Na 3DLigand Explorer Link out to Ligand Expos:NA Link out to SuperLigands:NA Link out to SuperHapten:NA
     
     
  •  
    Move Section Derived Data Hide
     
     
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Biological assembly assigned by authors and generated by PISA (software)
 
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Das, K.,   Arnold, E.

    Deposition:   2006-09-08
    Release:   2006-12-19
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 2.50
    R-Value: 0.233 (work)
    R-Free: 0.284
    Space Group: C 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 237.40 α = 90.00 
    b = 71.13 β = 105.86 
    c = 94.21 γ = 90.00