Crystal structure of HIV-1 reverse transcriptase (RT) in complex with DHBNH, an RNASE H inhibitor     DOI:10.2210/pdb2i5j/pdb

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Primary Citation       Molecular Description Hide Classification: Transferase Structure Weight: 115399.52   Molecule: Reverse transcriptase/ribonuclease H P66 subunit Polymer: 1 Type: polypeptide(L) Length: 552 Chains: A EC#: 2.7.7.49    Fragment: residues 599-1150 Mutation: C280S Molecule: Reverse transcriptase/ribonuclease H P51 subunit Polymer: 2 Type: polypeptide(L) Length: 429 Chains: B EC#: 2.7.7.49    Fragment: residues 599-1027 Mutation: C280S       Source Hide Polymer: 1 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli   Polymer: 2 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli         Ligand Chemical Component Hide Identifier Name Formula Interaction View Links GLC     ALPHA-D-GLUCOSE C6 H12 O6 Ligand Explorer K05     (E)-3,4-DIHYDROXY-N'-[(2-METHOXYNAPHTHALEN- 1-YL)METHYLENE]BENZOHYDRAZIDE C19 H16 N2 O4 Ligand Explorer MG     MAGNESIUM ION Mg Ligand Explorer SUC     SUCROSE C12 H22 O11 Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (1 Domains) CATH Classification v3.2.0 - (9 Domains) PFAM Classification - (7 Domains) GO Terms - (68 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Himmel, D.M.,   Sarafianos, S.G.,   Knight, J.L.,   Levy, R.M.,   Arnold, E. Deposition:   2006-08-24 Release:   2006-12-05 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 3.15 R-Value: 0.235 (obs.) R-Free: 0.269 Space Group: C 2 Unit Cell:   Length [Å] Angles [°] a = 224.82 α = 90.00  b = 68.90 β = 106.48  c = 104.66 γ = 90.00        Structure Links Hide Molecule of the Month Features: Reverse Transcriptase