2HWZ

Fab fragment of Humanized anti-viral antibody MEDI-493 (Synagis TM)

Experimental Data Snapshot

  • Method: X-RAY DIFFRACTION
  • Resolution: 1.80 Å

wwPDB Validation   3D Report Full Report


This is version 1.4 of the entry. See complete history. 


Literature

Identification of a single tryptophan residue as critical for binding activity in a humanized monoclonal antibody against respiratory syncytial virus

Wei, Z., Feng, J., Lin, H.-Y., Mullapudi, S., Bishop, E., Tous, G., Casas-Finet, J., Hakki, F., Strouse, R., Schenerman, M.

To be published.

Macromolecules
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Entity ID: 1
MoleculeChains Sequence LengthOrganismDetailsImage
Immunoglobulin Fab light chainA [auth L]213Homo sapiens, Mus musculus
This entity is chimeric		Mutation(s): 0 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
Sequence Annotations
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  • Reference Sequence
Find similar proteins by: 
(by identity cutoff)  |  3D Structure
Entity ID: 2
MoleculeChains Sequence LengthOrganismDetailsImage
Immunoglobulin Fab heavy chainB [auth H]227Homo sapiens, Mus musculus
This entity is chimeric		Mutation(s): 0 
Entity Groups  
Sequence Clusters30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity
Sequence Annotations
Expand
  • Reference Sequence
Experimental Data & Validation

Experimental Data

  • Method: X-RAY DIFFRACTION
  • Resolution: 1.80 Å
  • Space Group: P 21 21 21
Unit Cell:
Length ( Å )Angle ( ˚ )
a = 77.106α = 90
b = 105.925β = 90
c = 69.404γ = 90
Software Package:
Software NamePurpose
X-PLORmodel building
X-PLORrefinement
DENZOdata reduction
SCALEPACKdata scaling
X-PLORphasing

Structure Validation

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Entry History 

Deposition Data

  • Released Date: 2007-08-14 
    • Deposition Author(s): Braden, B.

Revision History  (Full details and data files)

  • Version 1.0: 2007-08-14
    Type: Initial release
  • Version 1.1: 2011-07-13
    Changes: Derived calculations, Version format compliance
  • Version 1.2: 2013-09-18
    Changes: Source and taxonomy
  • Version 1.3: 2014-02-05
    Changes: Source and taxonomy
  • Version 1.4: 2021-02-03
    Changes: Database references