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Crystal Structure of the inactive EGFR kinase domain in complex with AMP-PNP
2GS7
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 77700.56
    Molecule: Epidermal growth factor receptor
    Polymer: 1 Type: protein Length: 330
    Chains: A, B
    EC#: 2.7.10.1   
    Fragment: kinase domain, residues 696-1022
    Mutation: V924R
    Organism: Homo sapiens
    Gene Names: Gene View for EGFR ERBB ERBB1 HER1
    UniProtKB: Protein Feature View | Search PDB | P00533  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
     
  •   Related PDB Entries Hide
    Identifier Details
    2GS2  Crystal Structure of the active EGFR kinase domain 
    2GS6  Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    ANP
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    ANP C10 H17 N6 O12 P3
    PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
    ANP:2GS7
    IOD
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    IOD I
    IODIDE ION
    MG
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    MG Mg
    MAGNESIUM ION
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors and generated by PISA (software)
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