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Crystal Structure of the Kelch-Neh2 Complex
 
 
DOI:10.2210/pdb2flu/pdb
2FLU
 
Primary Citation
spinning wheel
 
 
  •  
    Move Section Molecular Description Hide
    Classification: Ligase
    Structure Weight: 35552.83
     
    Molecule:Kelch-like ECH-associated protein 1
    Polymer:1Type:polypeptide(L)Length:308
    Chains:X
    Fragment:Kelch domain of human Keap1
    Molecule:Nrf2
    Polymer:2Type:polypeptide(L)Length:16
    Chains:P
    Fragment:16-mer peptide from huma Neh2
     
     
  •  
    Move Section Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens Go to NCBI Taxonomy entry Common Name: Human Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct Go to NCBI Taxonomy entry  
     
     
  •  
    Move Section Related PDB Entries Hide
    Id Details
    1U6D  Crystal structure of the kelch domain of human Keap1 at 1.85 A 
    1ZGK  Crystal structure of the kelch domain of human Keap1 at 1.35 A 
     
     
  •  
    Move Section Derived Data Hide
     
     
 
 
  •  
    Move Section Deposition Summary Hide
    Authors:   Li, X.,   Lo, J.,   Beamer, L.,   Hannink, M.

    Deposition:   2006-01-06
    Release:   2006-08-15
    Last Modified (REVDAT):   2009-02-24
     
     
  •  
    Move Section Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Experimental Data:   Download Structure Factors  [ EDS External Link to EDS ]
    View a histogram of Resolution Resolution[Å]: 1.50
    R-Value: 0.180 (obs.)
    R-Free: 0.199
    Space Group: P 21 21 2
    Unit Cell:
      Length [Å] Angles [°]
    a = 76.76 α = 90.00 
    b = 92.07 β = 90.00 
    c = 46.31 γ = 90.00