HIV-1 Protease mutant L90M complexed with inhibitor TMC114     DOI:10.2210/pdb2f81/pdb

2F81 Display Files close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header) Download Files close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A+S) Print this Page Share this Page close Email Delicious Stumble Google More... Link this Page

Primary Citation       Molecular Description Hide Classification: Hydrolase Structure Weight: 22343.35   Molecule: POL POLYPROTEIN Polymer: 1 Type: polypeptide(L) Length: 99 Chains: A, B EC#: 3.4.23.16    Fragment: PROTEASE (RETROPEPSIN) Mutation: Q7K, L33I, L63I, C67A, L90M, C95A       Source Hide Polymer: 1 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli bl21(de3)         Related PDB Entries Hide Id Details 2F80    2F8G          Ligand Chemical Component Hide Identifier Name Formula Interaction View Links 017     (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3- YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL] (ISOBUTYL)AMINO]- 1-BENZYL-2-HYDROXYPROPYLCARBAMATE C27 H37 N3 O7 S Ligand Explorer CL     CHLORIDE ION Cl Ligand Explorer GOL     GLYCEROL C3 H8 O3 Ligand Explorer NA     SODIUM ION Na Ligand Explorer       Derived Data Hide SCOP Classification v1.75 - (2 Domains) CATH Classification v3.2.0 - (2 Domains) PFAM Classification - (2 Domains) GO Terms - (34 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Kovalevsky, A.Y.,   Weber, I.T. Deposition:   2005-12-01 Release:   2006-03-07 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 1.25 R-Value: 0.141 (work) R-Free: 0.189 Space Group: P 21 21 2 Unit Cell:   Length [Å] Angles [°] a = 58.26 α = 90.00  b = 85.91 β = 90.00  c = 46.05 γ = 90.00        Structure Links Hide Molecule of the Month Features: HIV-1 Protease