Kinetics, stability, and structural changes in high resolution crystal structures of HIV-1 protease with drug resistant mutations L24I, I50V, AND G73S     DOI:10.2210/pdb2avo/pdb

2AVO Display Files close FASTA Sequence PDB File PDB File (Header) mmCIF File mmCIF File (Header) PDBML/XML File PDBML/XML File (Header) Download Files close FASTA Sequence PDB File (Text) PDB File (gz) mmCIF File mmCIF File (gz) PDBML/XML File PDBML/XML File (gz) Structure Factor (Text) Structure Factor (gz) Biological Assembly (gz) (A+S) Print this Page Share this Page close Email Delicious Stumble Google More... Link this Page

Primary Citation       Molecular Description Hide Classification: Hydrolase Structure Weight: 22481.78   Molecule: Pol polyprotein Polymer: 1 Type: polypeptide(L) Length: 99 Chains: A, B EC#: 3.4.23.16    Fragment: protease retropepsin       Source Hide Polymer: 1 Scientific Name: Human immunodeficiency virus 1 Expression System: Escherichia coli         Ligand Chemical Component Hide Identifier Name Formula Interaction View Links ACY     ACETIC ACID C2 H4 O2 Ligand Explorer DMS     DIMETHYL SULFOXIDE C2 H6 O S Ligand Explorer GOL     GLYCEROL C3 H8 O3 Ligand Explorer MK1     N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)- 4(3 -PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY- 2(R)-PHENYLMETHYLPENTANAMIDE C36 H47 N5 O4 Ligand Explorer SO4     SULFATE ION O4 S Ligand Explorer       Derived Data Hide CATH Classification v3.2.0 - (2 Domains) PFAM Classification - (2 Domains) GO Terms - (34 Terms)     Reset Layout

Biological Assembly     More Images... View in Jmol Other Viewers close KiNG WebMol QuickPDB FirstGlance Kiosk SimpleViewer Protein Workshop Ligand Explorer Biological assembly assigned by authors and generated by PISA (software)         Deposition Summary Hide Authors:   Liu, F.,   Boross, P.I.,   Wang, Y.F.,   Tozser, J.,   Louis, J.M.,   Harrison, R.W.,   Weber, I.T. Deposition:   2005-08-30 Release:   2006-01-24 Last Modified (REVDAT):   2009-02-24       Experimental Details Hide Method:   X-RAY DIFFRACTION Experimental Data:    [ EDS ] Resolution[Å]: 1.10 R-Value: 0.107 (obs.) R-Free: 0.138 Space Group: P 21 21 21 Unit Cell:   Length [Å] Angles [°] a = 51.47 α = 90.00  b = 58.57 β = 90.00  c = 61.64 γ = 90.00        Structure Links Hide Molecule of the Month Features: HIV-1 Protease