Mammalian Shaker Kv1.2 potassium channel- beta subunit complex
2A79
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Membrane Protein
    Structure Weight: 101330.23
    Molecule: Voltage-gated potassium channel beta-2 subunit
    Polymer: 1 Type: protein Length: 333
    Chains: A
    Organism: Rattus norvegicus
    Gene Names: Kcnab2 Ckbeta2 Kcnb3
    UniProtKB: Protein Feature View | Search PDB | P62483  
    Molecule: Potassium voltage-gated channel subfamily A member 2
    Polymer: 2 Type: protein Length: 499
    Chains: B
    Organism: Rattus norvegicus
    Gene Name: Kcna2
    UniProtKB: Protein Feature View | Search PDB | P63142  
    Molecule: poly-unknown chain
    Polymer: 3 Type: protein Length: 52
    Chains: C
    Fragment: T1-S1 linker and S1 helix of the Kv1.2 channel
    Details: Chain C consists of a polyglycine model for the T1-S1 linker and a polyalanine model for the S1 helix of Kv1.2.
    Organism: Rattus norvegicus
    Molecule: poly-unknown chain
    Polymer: 4 Type: protein Length: 21
    Chains: D
    Fragment: S3 helix of the Kv1.2 channel
    Details: Chain D consists of a polyalanine model for the S3 helix of Kv1.2.
    Organism: Rattus norvegicus
    Membrane Protein:   Source: mpstruc
    ALPHA-HELICAL
    Channels: Potassium, Sodium, & Proton Ion-Selective
    Kv1.2/Kv2.1 Voltage-gated potassium channel chimera
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Rattus norvegicus   Taxonomy   Common Name: Norway rat Expression System: Pichia pastoris  
    Polymer: 2
    Scientific Name: Rattus norvegicus   Taxonomy   Common Name: Norway rat Expression System: Pichia pastoris  
    Polymer: 3
    Scientific Name: Rattus norvegicus   Taxonomy   Common Name: Norway rat Expression System: Pichia pastoris  
    Polymer: 4
    Scientific Name: Rattus norvegicus   Taxonomy   Common Name: Norway rat Expression System: Pichia pastoris  
     
  •   Related PDB Entries Hide
    Identifier Details
    1EXB   T1-beta complex 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    K
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    K K
    POTASSIUM ION
    NAP
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    NAP C21 H28 N7 O17 P3
    NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    UNK
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    UNK C4 H9 N O2 lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors
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  •   Deposition Summary Hide
    Authors:   Long, S.B.,  Campbell, E.B.,  MacKinnon, R.

    Deposition:   2005-07-05
    Release:   2005-07-12
    Last Modified (REVDAT):   2009-02-24
     
  •   Revision History    Hide
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   2.90
    R-Value: 0.222 (obs.)
    R-Free: 0.252
    Space Group: I 4
    Unit Cell:
      Length [Å] Angles [°]
    a = 113.61 α = 90.00 
    b = 113.61 β = 90.00 
    c = 260.47 γ = 90.00