1ZJ0
Crystal Structure of Human Galactosyltransferase (GTB) Complexed with Lactose
- PDB DOI: https://doi.org/10.2210/pdb1ZJ0/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2005-04-27 Released: 2005-12-13
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.67 Å
- R-Value Free: 0.230
- R-Value Work: 0.197
wwPDB Validation 3D Report Full Report
This is version 2.1 of the entry. See complete history.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) | 293 | Homo sapiens | Mutation(s): 0 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P16442 (Homo sapiens) Explore P16442 Go to UniProtKB: P16442 | |||||
PHAROS: P16442 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P16442 | ||||
Sequence AnnotationsExpand | |||||
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Oligosaccharides
Small Molecules
| Ligands 2 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| HG Query on HG | C [auth A], D [auth A], E [auth A], F [auth A], G [auth A] | MERCURY (II) ION Hg BQPIGGFYSBELGY-UHFFFAOYSA-N |  | ||
| CL Query on CL | H [auth A] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |  | ||
Biologically Interesting Molecules (External Reference) 1 Unique
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| ID | Chains | Name | Type/Class | 2D Diagram | 3D Interactions |
| PRD_900008 Query on PRD_900008 | B | alpha-lactose | Oligosaccharide / Nutrient |  | |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.67 Å
- R-Value Free: 0.230
- R-Value Work: 0.197
- Space Group: C 2 2 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 52.69 | α = 90 |
| b = 149.69 | β = 90 |
| c = 80 | γ = 90 |
| Software Name | Purpose |
|---|---|
| CrystalClear | data collection |
| CrystalClear | data reduction |
| CNS | refinement |
| CrystalClear | data scaling |
| CNS | phasing |
Entry History
Deposition Data
- Released Date: 2005-12-13 Deposition Author(s): Letts, J.A., Rose, N.L., Fang, Y.R., Barry, C.H., Borisova, S.N., Seto, N.O., Palcic, M.M., Evans, S.V.
Revision History (Full details and data files)
- Version 1.0: 2005-12-13
Type: Initial release - Version 1.1: 2008-04-30
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Derived calculations, Version format compliance - Version 1.3: 2016-02-17
Changes: Non-polymer description - Version 2.0: 2020-07-29
Type: Remediation
Reason: Carbohydrate remediation
Changes: Atomic model, Data collection, Database references, Derived calculations, Non-polymer description, Structure summary - Version 2.1: 2023-08-23
Changes: Data collection, Database references, Refinement description, Structure summary
