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Crystal structure of Src kinase domain in complex with Purvalanol A
1YOM
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transferase
    Structure Weight: 65678.80
    Molecule: Proto-oncogene tyrosine-protein kinase Src
    Polymer: 1 Type: protein Length: 283
    Chains: A, B
    EC#: 2.7.10.2   
    Fragment: Src kinase domain
    Mutation: S344N, A369S, Y418W
    Organism: Homo sapiens
    Gene Names: Gene View for SRC SRC1
    UniProtKB: Protein Feature View | Search PDB | P12931  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Spodoptera frugiperda  
     
  •   Related PDB Entries Hide
    Identifier Details
    1YOJ  Crystal structure of Src kinase domain 
    1YOL  Crystal structure of Src kinase domain in complex with CGP77675 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    P01
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    P01 C19 H25 Cl N6 O
    2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL- 9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL
    P01:1YOM
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    P01
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    P01
    IC50: 240 nM (98) - data from BindingDB  
    N/Ain BindingMoad
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors
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