Download MendeleySelective Inhibitors of Prostaglandin Synthase activity of human glutathione S-transferase M2-2
Patskovsky, Y.V., Patskovska, L.N., Listowsky, I., Almo, S.C.To be published.
1YKC
human glutathione S-transferase m2-2 (E.C.2.5.1.18) complexed with glutathione-disulfide
- PDB DOI: https://doi.org/10.2210/pdb1YKC/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2005-01-17 Released: 2005-01-25
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.10 Å
- R-Value Free: 0.254
- R-Value Work: 0.206
- R-Value Observed: 0.206
This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Glutathione S-transferase Mu 2 | 217 | Homo sapiens | Mutation(s): 0 Gene Names: GSTM2, GST4 EC: 2.5.1.18 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P28161 (Homo sapiens) Explore P28161 Go to UniProtKB: P28161 | |||||
PHAROS: P28161 GTEx: ENSG00000213366 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P28161 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GDS Query on GDS | C [auth A], D [auth B] | OXIDIZED GLUTATHIONE DISULFIDE C20 H32 N6 O12 S2 YPZRWBKMTBYPTK-BJDJZHNGSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.10 Å
- R-Value Free: 0.254
- R-Value Work: 0.206
- R-Value Observed: 0.206
- Space Group: P 21 21 21
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 56.61 | α = 90 |
| b = 74.79 | β = 90 |
| c = 116.5 | γ = 90 |
| Software Name | Purpose |
|---|---|
| SCALEPACK | data scaling |
| CCP4 | model building |
| CNS | refinement |
| MOLREP | phasing |
| CCP4 | phasing |
Entry History
Deposition Data
- Released Date: 2005-01-25 Deposition Author(s): Patskovsky, Y.V., Patskovska, L.N., Listowsky, I., Almo, S.C.
Revision History (Full details and data files)
- Version 1.0: 2005-01-25
Type: Initial release - Version 1.1: 2008-04-30
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2017-10-11
Changes: Refinement description - Version 1.4: 2023-08-23
Changes: Data collection, Database references, Derived calculations, Refinement description
