Triosephosphate isomerase from Plasmodium falciparum: the crystal structure provides insights into antimalarial drug design.
Velanker, S.S., Ray, S.S., Gokhale, R.S., Suma, S., Balaram, H., Balaram, P., Murthy, M.R.(1997) Structure 5: 751-761
- PubMed: 9261072 
- DOI: https://doi.org/10.1016/s0969-2126(97)00230-x
- Primary Citation of Related Structures:  
1YDV - PubMed Abstract: 
Malaria caused by the parasite Plasmodium falciparum is a major public health concern. The parasite lacks a functional tricarboxylic acid cycle, making glycolysis its sole energy source. Although parasite enzymes have been considered as potential antimalarial drug targets, little is known about their structural biology. Here we report the crystal structure of triosephosphate isomerase (TIM) from P. falciparum at 2.2 A resolution.
Organizational Affiliation: 
Molecular Biophysics Unit, Indian Institute of Science, Bangalore, India.