Download MendeleyCrystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI.
Lukacik, P., Bunkoczi, G., Kavanagh, K., Ng, S., von Delft, F., Bray, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U.To be published.
1YB1
Crystal structure of human 17-beta-hydroxysteroid dehydrogenase type XI
- PDB DOI: https://doi.org/10.2210/pdb1YB1/pdb
- Classification: OXIDOREDUCTASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2004-12-18 Released: 2004-12-28
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.192
- R-Value Work: 0.162
- R-Value Observed: 0.163
This is version 1.6 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| 17-beta-hydroxysteroid dehydrogenase type XI | 272 | Homo sapiens | Mutation(s): 0 Gene Names: DHRS8 EC: 1.1.1.62 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for Q8NBQ5 (Homo sapiens) Explore Q8NBQ5 Go to UniProtKB: Q8NBQ5 | |||||
PHAROS: Q8NBQ5 GTEx: ENSG00000198189 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q8NBQ5 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 4 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| AOI Query on AOI | H [auth A], L [auth B] | Androsterone C19 H30 O2 QGXBDMJGAMFCBF-HLUDHZFRSA-N |  | ||
| SO4 Query on SO4 | F [auth A], G [auth A] | SULFATE ION O4 S QAOWNCQODCNURD-UHFFFAOYSA-L |  | ||
| GOL Query on GOL | M [auth B] | GLYCEROL C3 H8 O3 PEDCQBHIVMGVHV-UHFFFAOYSA-N |  | ||
| CL Query on CL | C [auth A] D [auth A] E [auth A] I [auth B] J [auth B] | CHLORIDE ION Cl VEXZGXHMUGYJMC-UHFFFAOYSA-M |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.95 Å
- R-Value Free: 0.192
- R-Value Work: 0.162
- R-Value Observed: 0.163
- Space Group: P 41 21 2
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 110.939 | α = 90 |
| b = 110.939 | β = 90 |
| c = 118.013 | γ = 90 |
| Software Name | Purpose |
|---|---|
| REFMAC | refinement |
| MOSFLM | data reduction |
| CCP4 | data scaling |
| PHASER | phasing |
Entry History
Deposition Data
- Released Date: 2004-12-28 Deposition Author(s): Lukacik, P., Bunkoczi, G., Kavanagh, K., Ng, S., von Delft, F., Bray, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Revision History (Full details and data files)
- Version 1.0: 2004-12-28
Type: Initial release - Version 1.1: 2008-04-30
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Advisory, Version format compliance - Version 1.3: 2013-07-03
Changes: Non-polymer description - Version 1.4: 2018-01-31
Changes: Database references, Structure summary - Version 1.5: 2024-02-14
Changes: Data collection, Database references, Derived calculations - Version 1.6: 2024-04-03
Changes: Refinement description
