1Y9R

Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension

(2005) Nat Struct Mol Biol 12: 554-555

• PubMed: 15908963 Search on PubMed
• DOI: https://doi.org/10.1038/nsmb939
• Primary Citation of Related Structures:  
  1Y9R, 1YA3


• PubMed Abstract: 
  

  The S810L mutation within the human mineralocorticoid receptor (MR S810L) induces severe hypertension and switches progesterone from antagonist to agonist. Here we report the crystal structures of the ligand-binding domain of MR S810L in complex with progesterone and deoxycorticosterone, an agonist of both wild-type and mutant MRs. These structures, the first for MR, identify the specific contacts created by Leu810 and clarify the mechanism of activation of MR S810L.

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Organizational Affiliation: 

INSERM U478, Faculté de Médecine Xavier Bichat, 16 rue Henri Huchard, B.P. 416, 75870 Paris Cedex 18, France. fagart@bichat.inserm.fr