Download MendeleyX-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site
Rufer, A.C., Thiebach, L., Baer, K., Klein, H.W., Hennig, M.(2005) Acta Crystallogr Sect F Struct Biol Cryst Commun 61: 263-265
- PubMed: 16511012
- DOI: https://doi.org/10.1107/S1744309105004823
- Primary Citation of Related Structures:
1Y6E - PubMed Abstract:
The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs.
Organizational Affiliation:
F. Hoffmann-La Roche AG, Pharma Research Discovery Chemistry, 4070 Basel, Switzerland. arne.rufer@roche.com
