Download MendeleyStructural Perturbation of the Active Site of Human Glutathione-S-Transferase M2-2 Upon Ligand Binding
Patskovsky, Y., Patskovska, L.N., Almo, S.C., Listowsky, I.To be published.
1XW5
Human glutathione s-transferase M2-2 (E.C.2.5.1.18)complexed with glutathione, monoclinic crystal form
- PDB DOI: https://doi.org/10.2210/pdb1XW5/pdb
- Classification: TRANSFERASE
- Organism(s): Homo sapiens
- Expression System: Escherichia coli BL21(DE3)
- Mutation(s): No
- Deposited: 2004-10-29 Released: 2004-11-30
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.232
- R-Value Work: 0.206
- R-Value Observed: 0.206
This is version 1.4 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| Glutathione S-transferase Mu 2 | 217 | Homo sapiens | Mutation(s): 0 Gene Names: GSTM2, GST4 EC: 2.5.1.18 |  | |
UniProt & NIH Common Fund Data Resources | |||||
Find proteins for P28161 (Homo sapiens) Explore P28161 Go to UniProtKB: P28161 | |||||
PHAROS: P28161 GTEx: ENSG00000213366 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | P28161 | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Ligands 1 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Name / Formula / InChI Key | 2D Diagram | 3D Interactions | |
| GSH Query on GSH | C [auth A], D [auth B] | GLUTATHIONE C10 H17 N3 O6 S RWSXRVCMGQZWBV-WDSKDSINSA-N |  | ||
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 1.80 Å
- R-Value Free: 0.232
- R-Value Work: 0.206
- R-Value Observed: 0.206
- Space Group: P 1 21 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 51.2 | α = 90 |
| b = 49.79 | β = 94.27 |
| c = 92.04 | γ = 90 |
| Software Name | Purpose |
|---|---|
| SCALEPACK | data scaling |
| CCP4 | model building |
| CNS | refinement |
| CCP4 | phasing |
Entry History
Deposition Data
- Released Date: 2004-11-30 Deposition Author(s): Patskovska, L.N., Patskovsky, Y.V., Almo, S.C., Listowsky, I.
Revision History (Full details and data files)
- Version 1.0: 2004-11-30
Type: Initial release - Version 1.1: 2008-04-30
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2017-10-11
Changes: Refinement description - Version 1.4: 2023-08-23
Changes: Data collection, Database references, Derived calculations, Refinement description
