Download MendeleyCyclophilin from Trypanosoma Cruzi Bound to Cyclosporin A
Caruthers, J.M., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa ConsortiumTo be published.
1XQ7
Cyclophilin from Trypanosoma cruzi bound to cyclosporin A
- PDB DOI: https://doi.org/10.2210/pdb1XQ7/pdb
- Classification: ISOMERASE/IMMUNOSUPPRESSANT
- Organism(s): Trypanosoma cruzi, Tolypocladium inflatum
- Expression System: Escherichia coli
- Mutation(s): No
- Deposited: 2004-10-11 Released: 2004-12-21
Experimental Data Snapshot
- Method: X-RAY DIFFRACTION
- Resolution: 2.07 Å
- R-Value Free: 0.235
- R-Value Work: 0.169
- R-Value Observed: 0.172
wwPDB Validation 3D Report Full Report
This is version 1.7 of the entry. See complete history.
Literature
To be published.
Macromolecules
Find similar proteins by:
(by identity cutoff) | 3D Structure
Entity ID: 1 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| PEPTIDYL-PROLYL CIS-TRANS ISOMERASE | 166 | Trypanosoma cruzi | Mutation(s): 0 EC: 5.2.1.8 |  | |
UniProt | |||||
Find proteins for Q4DPB9 (Trypanosoma cruzi (strain CL Brener)) Explore Q4DPB9 Go to UniProtKB: Q4DPB9 | |||||
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
| UniProt Group | Q4DPB9 | ||||
Sequence AnnotationsExpand | |||||
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Find similar proteins by: Sequence | 3D Structure
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| Molecule | Chains | Sequence Length | Organism | Details | Image |
| CYCLOSPORIN A | 11 | Tolypocladium inflatum | Mutation(s): 0 |  | |
Entity Groups | |||||
| Sequence Clusters | 30% Identity50% Identity70% Identity90% Identity95% Identity100% Identity | ||||
Sequence AnnotationsExpand | |||||
| |||||
Small Molecules
| Modified Residues 5 Unique | |||||
|---|---|---|---|---|---|
| ID | Chains | Type | Formula | 2D Diagram | Parent |
| ABA Query on ABA | D, E, F | L-PEPTIDE LINKING | C4 H9 N O2 |  | ALA |
| BMT Query on BMT | D, E, F | L-PEPTIDE LINKING | C10 H19 N O3 |  | THR |
| MLE Query on MLE | D, E, F | L-PEPTIDE LINKING | C7 H15 N O2 |  | LEU |
| MVA Query on MVA | D, E, F | L-PEPTIDE LINKING | C6 H13 N O2 |  | VAL |
| SAR Query on SAR | D, E, F | PEPTIDE LINKING | C3 H7 N O2 |  | GLY |
Biologically Interesting Molecules (External Reference) 1 Unique
Entity ID: 2 | |||||
|---|---|---|---|---|---|
| ID | Chains | Name | Type/Class | 2D Diagram | 3D Interactions |
| PRD_000142 Query on PRD_000142 | D, E, F | Cyclosporin A | Cyclic peptide / Immunosuppressant |  | |
Experimental Data & Validation
Experimental Data
- Method: X-RAY DIFFRACTION
- Resolution: 2.07 Å
- R-Value Free: 0.235
- R-Value Work: 0.169
- R-Value Observed: 0.172
- Space Group: P 1
Unit Cell:
| Length ( Å ) | Angle ( ˚ ) |
|---|---|
| a = 52.269 | α = 110.49 |
| b = 57.059 | β = 108.21 |
| c = 58.807 | γ = 105.4 |
| Software Name | Purpose |
|---|---|
| EPMR | phasing |
| REFMAC | refinement |
| ELVES | data reduction |
| ELVES | data scaling |
Entry History
Deposition Data
- Released Date: 2004-12-21 Deposition Author(s): Caruthers, J.M., Hol, W.G.J., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Revision History (Full details and data files)
- Version 1.0: 2004-12-21
Type: Initial release - Version 1.1: 2011-06-14
Changes: Version format compliance - Version 1.2: 2011-07-13
Changes: Version format compliance - Version 1.3: 2011-07-27
Changes: Atomic model, Database references, Derived calculations, Non-polymer description, Structure summary - Version 1.4: 2012-12-12
Changes: Other - Version 1.5: 2018-01-31
Changes: Database references - Version 1.6: 2023-08-23
Changes: Data collection, Database references, Derived calculations, Refinement description - Version 1.7: 2023-11-15
Changes: Data collection, Derived calculations
