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NMR structure of the complex between Nck-2 SH3 domain and PINCH-1 LIM4 domain
1U5S
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Metal Binding Protein
    Structure Weight: 15726.70
    Molecule: Cytoplasmic protein NCK2
    Polymer: 1 Type: protein Length: 71
    Chains: A
    Fragment: third SH3 domain (residues 192-262)
    Organism: Homo sapiens
    Gene Names: Gene View for NCK2 GRB4
    UniProtKB: Protein Feature View | Search PDB | O43639  
    Molecule: PINCH protein
    Polymer: 2 Type: protein Length: 66
    Chains: B
    Fragment: fourth LIM domain (residues 188-251)
    Organism: Homo sapiens
    Gene Names: Gene View for LIMS1 PINCH PINCH1
    UniProtKB: Protein Feature View | Search PDB | P48059  
     

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  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli bl21(de3)  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli bl21(de3)  
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    ZN
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    ZN Zn
    ZINC ION
     
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Data in orange boxes are gathered from external resources (when available).
 
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  •   Deposition Summary Hide
    Authors:   Vaynberg, J.,  Fukuda, T.,  Vinogradova, O.,  Velyvis, A.,  Ng, L.,  Wu, C.,  Qin, J.

    Deposition:   2004-07-28
    Release:   2005-04-05
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   SOLUTION NMR
    Exp. Data:
    BMRB  
    NMR Ensemble
    Conformers Calculated:     50
    Conformers Submitted:     18
    Selection Criteria: structures with the most reperesentative side chains orientations on the complex interface
    NMR Refine
    Method: SOLUTION NMR