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Structure of mammalian cytochrome P450 2B4 with bound 4-(4-chlorophenyl)imidazole
1SUO
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Oxidoreductase
    Structure Weight: 54964.92
    Molecule: Cytochrome P450 2B4
    Polymer: 1 Type: protein Length: 476
    Chains: A
    EC#: 1.14.14.1   
    Mutation: E2A, G22K, H23K, P24T, K25S, A26S, H27K, R29K, P221S, H226Y
    Details: CYS 436 BINDS HEME IRON. 4-(4-CHLOROPHENYL)IMIDAZOLE IS BOUND IN THE ACTIVE SITE COORDINATING TO THE HEME IRON AS THE SIXTH LIGAND.
    Organism: Oryctolagus cuniculus
    Gene Name: CYP2B4
    UniProtKB: Protein Feature View | Search PDB | P00178  
     
  •   Structure Validation Hide

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  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Oryctolagus cuniculus   Taxonomy   Common Name: Rabbit Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1PO5  Structure of mammalian cytochrome P450 2B4 
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    CPZ
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    CPZ C9 H7 Cl N2
    4-(4-CHLOROPHENYL)IMIDAZOLE
    CPZ:1SUO
    HEM
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    HEM C34 H32 Fe N4 O4
    PROTOPORPHYRIN IX CONTAINING FE
     
  •   External Ligand Annotations Hide
    Identifier   Binding Affinity (Sequence Identity %)
    CPZ
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    CPZ
    -TΔS: -7.3 kJ/mol (100) - data from BindingDB  
    IC50: 40 nM - data from BindingMOAD  
    N/Ain PDBbind
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly       
Biological assembly 1 assigned by authors
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