Crystal Structure of Human NFAT1 and Fos-Jun on the IL-2 ARRE1 Site
DOI:10.2210/pdb1s9k/pdb   NDB ID: PD0519
1S9K
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Transcription/dna
    Structure Weight: 56646.42
    Molecule: Human IL-2 ARRE1 Promoter Element, Plus Strand
    Polymer: 1 Type: dna Length: 20
    Chains: A
    Molecule: Human IL-2 ARRE1 Promoter Element, Minus Strand
    Polymer: 2 Type: dna Length: 20
    Chains: B
    Molecule: Nuclear factor of activated T-cells, cytoplasmic 2
    Polymer: 3 Type: protein Length: 280
    Chains: C
    Organism: Homo sapiens
    Gene Names: Gene View for NFATC2 NFAT1 NFATP
    UniProtKB: Protein Feature View | Search PDB | Q13469  
    Molecule: Proto-oncogene protein c-fos
    Polymer: 4 Type: protein Length: 53
    Chains: D
    Organism: Homo sapiens
    Gene Names: Gene View for FOS G0S7
    UniProtKB: Protein Feature View | Search PDB | P01100  
    Molecule: Transcription factor AP-1
    Polymer: 5 Type: protein Length: 52
    Chains: E
    Organism: Homo sapiens
    Gene Name: Gene View for JUN
    UniProtKB: Protein Feature View | Search PDB | P05412  
     
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  •   Source Hide
    Polymer: 1
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 3
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 4
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
    Polymer: 5
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1a02   Structure Of The DNA Binding Domains Of Nfat, Fos and Jun Bound To DNA 
    1a66   Solution NMR Structure Of The Core Nfatc1/DNA Complex 
    1fos   C-Jun Proto-Oncogene (Transcription Factor Ap-1) Dimerized With C-Fos and Complexed With DNA 
    1imh   CRYSTAL STRUCTURE OF HUMAN NFAT1 BOUND MONOMERICALLY TO DNA 
     
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  • Nucleic Acid Database Hide
    View the NDB ID associated with this structure:PD0519
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors
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  •   Deposition Summary Hide
    Authors:   Wang, D.,  Stroud, J.C.,  Chen, L.

    Deposition:   2004-02-04
    Release:   2005-06-14
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
      Structure Factors
    EDS  
    Resolution[Å]:   3.10
    R-Value: 0.242 (obs.)
    R-Free: 0.275
    Space Group: P 1 21 1
    Unit Cell:
      Length [Å] Angles [°]
    a = 64.77 α = 90.00 
    b = 86.26 β = 111.24 
    c = 84.04 γ = 90.00