1REC

Three-Dimensional Structure of Recoverin, a Calcium Sensor in Vision

(1993) Cell 75: 709-716

• PubMed: 8242744 Search on PubMed
• DOI: https://doi.org/10.1016/0092-8674(93)90491-8
• Primary Citation of Related Structures:  
  1REC


• PubMed Abstract: 
  

  Recoverin, a recently discovered member of the EF hand superfamily, serves as a calcium sensor in vision. We report here the crystal structure of recombinant unmyristoylated recoverin at 1.9 A resolution. The four EF hands of the protein are arranged in a compact array that contrasts with the dumbbell shape of calmodulin and troponin C. A calcium ion is bound to EF hand 3, while EF hand 2 can bind samarium but not calcium in this crystal form. The other two EF hands have novel structural features that prevent or impair calcium binding. A concave hydrophobic surface formed by EF hands 1 and 2 may participate in the read out of calcium signals by recoverin and its homologs.

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Organizational Affiliation: 

Beckman Laboratories for Structural Biology, Department of Cell Biology, Stanford University School of Medicine, California 94305.