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Structural Basis for Differential Recognition of Tyrosine Phosphorylated Sites in the Linker for Activation of T cells (LAT) by the Adaptor Protein Gads
1R1Q
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Peptide Binding Protein
    Structure Weight: 25802.81
    Molecule: GRB2-related adaptor protein 2
    Polymer: 1 Type: protein Length: 100
    Chains: A, B
    Fragment: Gads-SH2 domain
    Organism: Mus musculus
    Gene Names: Grap2 Gads Grb2l Grid Mona
    UniProtKB: Protein Feature View | Search PDB | O89100  
    Molecule: LAT pY191 peptide
    Polymer: 2 Type: protein Length: 7
    Chains: C, D
     
  •   Structure Validation Hide

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  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Mus musculus   Taxonomy   Common Name: House mouse Expression System: Escherichia coli  
    Polymer: 2
    Scientific Name: Synthetic construct   Taxonomy    
     
  •   Related PDB Entries Hide
    Identifier Details
    1r1p   
    1r1s   
     
  •   Ligand Chemical Component Hide
    Identifier Formula Name View Interactions
    SO4
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    SO4 O4 S
    SULFATE ION
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    ACE
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    ACE C2 H4 O nonPolymer
    PTR
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    PTR C9 H12 N O6 P TYR lPeptideLinking
     
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  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
 
  Biological Assembly 1       
Biological assembly 1 assigned by authors and generated by PISA (software)
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  •   Deposition Summary Hide
    Authors:   Cho, S.,  Mariuzza, R.A.

    Deposition:   2003-09-24
    Release:   2004-09-28
    Last Modified (REVDAT):   2009-02-24
     
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    2011-07-13
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  •   Experimental Details Hide
    Method:   X-RAY DIFFRACTION
    Exp. Data:
    N/A
    Resolution[Å]:   1.80
    R-Value: 0.179 (obs.)
    R-Free: 0.225
    Space Group: P 21
    Unit Cell:
      Length [Å] Angles [°]
    a = 42.71 α = 90.00 
    b = 51.81 β = 101.38 
    c = 43.97 γ = 90.00