Human class II MHC protein HLA-DR1 bound to a designed peptide related to influenza virus hemagglutinin, FVKQNA(MAA)AL, in complex with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)
1PYW
Primary Citation
 
 
  •   Molecular Description Hide
    Classification: Immune System/protein Binding/toxin
    Structure Weight: 71960.40
    Molecule: HLA class II histocompatibility antigen, DR alpha chain
    Polymer: 1 Type: protein Length: 182
    Chains: A
    Fragment: Extracellular domain of HLA-DRA
    Organism: Homo sapiens
    Gene Names: Gene View for HLA-DRA HLA-DRA1
    UniProtKB: Protein Feature View | Search PDB | P01903  
    Molecule: HLA class II histocompatibility antigen, DR-1 beta chain
    Polymer: 2 Type: protein Length: 190
    Chains: B
    Fragment: Extracellular domain of HLA-DRB1
    Organism: Homo sapiens
    Gene Name: Gene View for HLA-DRB1
    UniProtKB: Protein Feature View | Search PDB | P04229  
    Molecule: 9-residue influenza virus hemagglutinin related peptide FVKQNA(MAA)AL
    Polymer: 3 Type: protein Length: 10
    Chains: C
    Mutation: Y308F, T313A, L314(MAA), K315A
    Molecule: Enterotoxin type C-3
    Polymer: 4 Type: protein Length: 239
    Chains: D
    Fragment: residues 28-266
    Mutation: K43S, L45F, A46K, H47W
    Organism: Staphylococcus aureus subsp. aureus Mu50
    Gene Names: entC3 SAV2009
    UniProtKB: Protein Feature View | Search PDB | P0A0L3  
     
  •   Structure Validation Hide

    View the full validation report  

     

  • MolProbity Ramachandran Plot
     

  •   Related Citations in PDB Entry (REMARK 1) Hide
     
  •   Source Hide
    Polymer: 1
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli bl21(de3)  
    Polymer: 2
    Scientific Name: Homo sapiens   Taxonomy   Common Name: Human Expression System: Escherichia coli bl21(de3)  
    Polymer: 3
    Scientific Name: Synthetic construct   Taxonomy    
    Polymer: 4
    Scientific Name: Staphylococcus aureus subsp. aureus mu50   Taxonomy   Expression System: Escherichia coli  
     
  •   Related PDB Entries Hide
    Identifier Details
    1DLH   Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide 
    1KLU   CRYSTAL STRUCTURE OF HLA-DR1/TPI(23-37) COMPLEXED WITH STAPHYLOCOCCAL ENTEROTOXIN C3 VARIANT 3B2 (SEC3-3B2) 
     
  •   Modified Residues Hide
    Identifier Formula Parent Type
    ACE
    Search 
    ACE C2 H4 O nonPolymer
    MAA
    Search 
    MAA C4 H9 N O2 ALA lPeptideLinking
     
  •   External Domain Annotations Hide
     
  •   Structural Biology Knowledgebase Data Hide
     
 
Data in orange boxes are gathered from external resources (when available).
  Biological Assembly       
Biological assembly 1 assigned by authors
Downloadable viewers: