Download MendeleyCrystal structure of transaldolase B from Escherichia coli suggests a circular permutation of the alpha/beta barrel within the class I aldolase family.
Jia, J., Huang, W., Schorken, U., Sahm, H., Sprenger, G.A., Lindqvist, Y., Schneider, G.(1996) Structure 4: 715-724
- PubMed: 8805555
- DOI: https://doi.org/10.1016/s0969-2126(96)00077-9
- Primary Citation of Related Structures:
1ONR - PubMed Abstract:
Transaldolase is one of the enzymes in the non-oxidative branch of the pentose phosphate pathway. It transfers a C3 ketol fragment from a ketose donor to an aldose acceptor. Transaldolase, together with transketolase, creates a reversible link between the pentose phosphate pathway and glycolysis. The enzyme is of considerable interest as a catalyst in stereospecific organic synthesis and the aim of this work was to reveal the molecular architecture of transaldolase and provide insights into the structural basis of the enzymatic mechanism.
Organizational Affiliation:
Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
