Download MendeleyA 26 kDa yeast DNA topoisomerase I fragment: crystallographic structure and mechanistic implications.
Lue, N., Sharma, A., Mondragon, A., Wang, J.C.(1995) Structure 3: 1315-1322
- PubMed: 8747458
- DOI: https://doi.org/10.1016/s0969-2126(01)00269-6
- Primary Citation of Related Structures:
1OIS - PubMed Abstract:
Type I DNA topoisomerases, divided mechanistically into two subfamilies, are ubiquitous enzymes that participate in replication and transcription. In addition to its role in these fundamental processes, the biological importance of eukaryotic DNA topoisomerase I is underscored by its identification as the target of the antitumor alkaloid camptothecin. An understanding of the mechanism of catalysis and interactions with camptothecin and other drugs has been hampered by a lack of detailed structural information.
Organizational Affiliation:
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
