Download MendeleyStructure of deoxy-quaternary haemoglobin with liganded beta subunits.
Luisi, B., Liddington, B., Fermi, G., Shibayama, N.(1990) J Mol Biol 214: 7-14
- PubMed: 2370669
- DOI: https://doi.org/10.1016/0022-2836(90)90139-d
- Primary Citation of Related Structures:
1NIH - PubMed Abstract:
We have determined the structure of a T-state haemoglobin in which the haem groups of the beta subunits have carbon monoxide bound, and the alpha subunits have nickel replacing the haem iron and are ligand-free. The structural adjustments on binding ligand in the T state are in the same direction as those associated with the quaternary transition, and a translational shift of the haem is severely restricted. We explain how these observations may account for the low ligand affinity of the beta haem of T-state haemoglobin.
Organizational Affiliation:
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511.
